Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery

siRNA delivery and targeting.

RNA interference (RNAi) is one of the most dramatic findings over the past decade, and the number of publications related to RNAi increased exponentially from 5 in 1998 to more than 2400 in 2008. Generally, RNAi can be achieved by three strategies: chemical synthesized small interfering RNA (siRNA), long double-stranded RNA (dsRNA), and DNA-based (plasmid or viral vector) short hairpin RNA (shR...

All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery.

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurren...

Fe3O4@Ag Nanoprobe for Detection of Ovarian Cancer Cell Line Using Magnetic Resonance Imaging

Background and Aims: Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cells. The aim of this study was to evaluate the use of magnetic nanoparticles containing iron oxide and silver (Fe3O4@Ag core-shell nanoprobe) as a contrast agent for the detection of ovarian cancer cell line ovcar-3. Materials and Methods: Co-preci...

Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells.

Cisplatin is one of the most widely used anticancer drugs. Its side effects, however, have motivated researchers to search for equally effective analogs that are better tolerated. Selectively targeting cancer tissue is one promising strategy. For this purpose, a platinum(IV) complex was conjugated to the cancer-targeting peptide chlorotoxin (CTX, TM601) in order to deliver cisplatin selectively...

Cell targeting and imaging using magnetic nanoparticles